Programmed Bacteria: Friend or Foe?
Some bacteria inhabiting the human body are non-pathogenic and some of them can be turned, after proper engineering, into ‘smart’ living therapeutics of defined properties for the treatment of different illnesses. The engineered bacteria can be used for the treatment of diverse human pathologies, including inflammatory bowel diseases, autoimmune disorders, cancer, metabolic diseases and obesity, as well as to combat bacterial and viral infections. Recently, Chowdhury S et al. reported engineered Escherichia coli strain which lyse within the tumor microenvironment and release an encoded nanobody antagonist of CD47 (CD47nb)12, an anti-phagocytic receptor that is commonly overexpressed in several human cancer types13,14. The result is activation of tumor-infiltrating T cells that stimulates rapid tumor regression and long-term survival in a syngeneic tumor model in mice. Read more Here: https://www.nature.com/articles/s41591-019-0498-z