In recent years, many strategies have been used to overcome the fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) resistance caused by different mutations. LY2874455 (or 6LF) is a pan-FGFR inhibitor which is identified as the most efficient TKI for all resistant mutations in FGFRs.
The Ames test, Salmonella typhimurium reverse mutation assay, is a bacterial short-term test accomplished in vitro to evaluate the mutagenicity of various environmental carcinogens and toxins such as drugs, dyes, reagents, cosmetics, pesticides and other substances which are easily solubilized in a liquid suspension.